Publications

Selected Publications

Wang D,  Diao H, Getzler AJ, Rogal W, Frederick MA, Milner JJ, Yu B, Crotty S, Goldrath AW, Pipkin ME.
The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation.
Immunity. 2018 April 17;48(4):659–674. doi: 10.1016/j.immuni.2018.03.028.

Milner JJ, Toma C, Yu B, Zhang K, Omilusik K, Phan AT, Wang D, Getzler AJ, Nguyen T, Crotty S, Wang W, Pipkin ME, Goldrath AW.
Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours.
Nature. 2017 Dec 14;552(7684):253-257. doi: 10.1038/nature24993. Epub 2017 Dec 6.

Yu B, Zhang K, Milner JJ, Toma C, Chen R, Scott-Browne JP, Pereira RM, Crotty S, Chang JT, Pipkin ME, Wang W, Goldrath AW.
Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation.
Nat Immunol. 2017 May;18(5):573-582. doi: 10.1038/ni.3706. Epub 2017 Mar 13.

Crotty S, Pipkin ME.
In vivo RNAi screens: concepts and applications.
Trends Immunol. 2015 May;36(5):315-22. doi: 10.1016/j.it.2015.03.007. Epub 2015 Apr 27. Review.

Martinez GJ, Pereira RM, Äijö T, Kim EY, Marangoni F, Pipkin ME, Togher S, Heissmeyer V, Zhang YC, Crotty S, Lamperti ED, Ansel KM, Mempel TR, Lähdesmäki H, Hogan PG, Rao A.
The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.
Immunity. 2015 Feb 17;42(2):265-278. doi: 10.1016/j.immuni.2015.01.006. Epub 2015 Feb 10.

Chen R, Bélanger S, Frederick MA, Li B, Johnston RJ, Xiao N, Liu YC, Sharma S, Peters B, Rao A, Crotty S, Pipkin ME.
In vivo RNA interference screens identify regulators of antiviral CD4(+) and CD8(+) T cell differentiation.
Immunity. 2014 Aug 21;41(2):325-38. doi: 10.1016/j.immuni.2014.08.002.

Trifari S, Pipkin ME, Bandukwala HS, Äijö T, Bassein J, Chen R, Martinez GJ, Rao A.
MicroRNA-directed program of cytotoxic CD8+ T-cell differentiation.
Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18608-13. doi: 10.1073/pnas.1317191110. Epub 2013 Oct 25.

Yigit E, Zhang Q, Xi L, Grilley D, Widom J, Wang JP, Rao A, Pipkin ME.
High-resolution nucleosome mapping of targeted regions using BAC-based enrichment.
Nucleic Acids Res. 2013 Apr;41(7):e87. doi: 10.1093/nar/gkt081. Epub 2013 Feb 14.

Pipkin ME
Memories in the snow: immune memory, persistent infection and chronic disease.
EMBO Rep, Jul 1;12(7):617-9.

Pipkin ME, Sacks JA, Cruz-Guilloty F, Lichtenheld MG, Bevan MJ, Rao A.
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells.
Immunity. 2010 Jan 29;32(1):79-90. doi: 10.1016/j.immuni.2009.11.012. Epub 2010 Jan 21.

Cruz-Guilloty F, Pipkin ME, Djuretic IM, Levanon D, Lotem J, Lichtenheld MG, Groner Y, Rao A.
Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs.
J Exp Med. 2009 Jan 16;206(1):51-9. doi: 10.1084/jem.20081242. Epub 2009 Jan 12.

Pipkin ME, Ljutic B, Cruz-Guilloty F, Nouzova M, Rao A, Zúñiga-Pflücker JC, Lichtenheld MG.
Chromosome transfer activates and delineates a locus control region for perforin.
Immunity. 2007 Jan;26(1):29-41. Epub 2007 Jan 11.

Pipkin ME, Lichtenheld MG.
A reliable method to display authentic DNase I hypersensitive sites at long-ranges in single-copy genes from large genomes.
Nucleic Acids Res. 2006 Mar 1;34(4):e34.

Pipkin Bibliography:
http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/41153715/?sort=date&direction=ascending